The combination of neutrophil to lymphocyte ratio and platelet to lymphocyte ratio improves accuracy of neonatal sepsis diagnosis

Background Neonatal sepsis remains a challenging issue, due to sophisticated and time consuming tests needed confirm diagnosis.
 Objective To assess the applicability of neutrophil lymphocyte ratio (NLR) platelet (PLR) as diagnostic markers in neonatal sepsis.
 Methods This cross-sectional study was conducted Neonatology Ward Kandou General Hospital, Manado, North Sulawesi. Neonates with suspected were included by consecutive sampling. We measured NLR PLR form hematology profiles differential count. Diagnosis based on positive blood cultures. A receiver operating characteristic (ROC) curve analysis done cut-off points. Chi-square test used analyze value PLR.
 Results total 176 full term neonates study. Of these, 84 (47.7%) subjects confirmed 92 (52.3%) non-sepsis. The mean NLRs 5.9 (95%CI 2.0 13.6) group 1.6 0.2 3.2) non-sepsis group. 3.0 determined predictive (sensitivity 94%, speci?city 97.8%, area under ROC 0.995). can effects diagnosis 61% . PLRs 79.9 44.0 155.8) 9.7 91.8) 60.4 86.9%, 87%, 0.928). 47.5%. When combined, they improve accuracy about 72.2%.
 Conclusion Neutrophil be combination adjunct for workups.